Por favor, use este identificador para citar o enlazar este ítem: http://hdl.handle.net/10637/15621

The role of oxylipins and their validation as biomarkers in the clinical context

Título : The role of oxylipins and their validation as biomarkers in the clinical context
Autor : Camunas-Alberca, Sandra M.
Moran Garrido, María
Sáiz Galindo, Jorge
Villaseñor Solis, Alma Cristina
Barbas Arribas, Coral.
Materias: LC-MS/MS analysisOxygenated fatty acidsPUFAsEicosanoidsProstaglandinsLeukotrienesPro-resolving lipid mediatorsBioactive lipid mediators
Editorial : Elsevier
Citación : Sandra M. Camunas-Alberca, Maria Moran-Garrido, Jorge Sáiz, Alma Villaseñor, Ameer Y. Taha, Coral Barbas, The role of oxylipins and their validation as biomarkers in the clinical context, TrAC Trends in Analytical Chemistry, Volume 164, 2023, 117065, ISSN 0165-9936, https://doi.org/10.1016/j.trac.2023.117065
Resumen : Oxylipins are bioactive lipid mediators that participate in a wide range of processes, from blood flow to inflammation. In recent years, their exhaustive characterization as potential biomarkers has been actively pursued. However, several analytical challenges and sources of variability, like the low abundance of oxylipins in samples, their structural diversity, and the lack of harmonized and validated protocols for sample selection, collection, storage, and preparation have hampered their translation into clinical settings. In this review, these sources of variability are addressed and are exemplified with their application in recent clinical studies in different diseases. Our overall analysis highlights the need to achieve harmonized protocols for generating reliable and reproducible results that could be integrated into clinical practice to reach their full diagnostic and prognostic potential.
URI : http://hdl.handle.net/10637/15621
Derechos: http://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
Open Access
ISSN : 1879-3142
Cubierto por: Acuerdo Transformativo – 2023
Fecha de publicación : jul-2023
Centro : Universidad San Pablo-CEU
Aparece en las colecciones: Facultad de Farmacia





Los ítems de DSpace están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.