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dc.contributor.otherUniversidad San Pablo-CEU. Facultad de Medicina.-
dc.contributor.otherGrupo: Centro de metabolómica y bioanálisis (CEMBIO)-
dc.creatorFernández García, Miguel-
dc.creatorRey-Stolle, María Fernanda-
dc.creatorBoccard, Julien-
dc.creatorReddy, Vineel P.-
dc.creatorGarcía Fernández, Antonia-
dc.creatorCumming, Bridgette M.-
dc.creatorSteyn, Adrie J. C.-
dc.creatorRudaz, Serge-
dc.creatorBarbas Arribas, Coral.-
dc.date.accessioned2024-02-09T13:46:23Z-
dc.date.available2024-02-09T13:46:23Z-
dc.date.issued2020-04-14-
dc.identifier.citationFernández-García M, Rey-Stolle F, Boccard J, Reddy VP, García A, Cumming BM, Steyn AJC, Rudaz S, Barbas C. Comprehensive Examination of the Mouse Lung Metabolome Following Mycobacterium tuberculosis Infection Using a Multiplatform Mass Spectrometry Approach. J Proteome Res. 2020 May 1;19(5):2053-2070. doi: 10.1021/acs.jproteome.9b00868. Epub 2020 Apr 23. PMID: 32285670; PMCID: PMC7199213.es_ES
dc.identifier.issn1535-3893-
dc.identifier.urihttp://hdl.handle.net/10637/15421-
dc.description.abstractThe mechanisms whereby Mycobacterium tuberculosis (Mtb) rewires the host metabolism in vivo are surprisingly unexplored. Here, we used three high-resolution mass spectrometry platforms to track altered lung metabolic changes associated with Mtb infection of mice. The multiplatform data sets were merged using consensus orthogonal partial least squaresdiscriminant analysis (cOPLS-DA), an algorithm that allows for the joint interpretation of the results from a single multivariate analysis. We show that Mtb infection triggers a temporal and progressive catabolic state to satisfy the continuously changing energy demand to control infection. This causes dysregulation of metabolic and oxido-reductive pathways culminating in Mtbassociated wasting. Notably, high abundances of trimethylamine-N-oxide (TMAO), produced by the host from the bacterial metabolite trimethylamine upon infection, suggest that Mtb could exploit TMAO as an electron acceptor under anaerobic conditions. Overall, these new pathway alterations advance our understanding of the link between Mtb pathogenesis and metabolic dysregulation and could serve as a foundation for new therapeutic intervention strategies. Mass spectrometry data has been deposited in the Metabolomics Workbench repository (data-set identifier: ST001328).en_EN
dc.formatapplication/pdf-
dc.language.isoen-
dc.publisherAmerican Chemical Society-
dc.relation.ispartofJournal of Proteome Research-
dc.rightshttp://creativecommons.org/licenses/by-nc-nd/4.0/deed.es-
dc.subjectTuberculosisen_EN
dc.subjectMetabolomicsen_EN
dc.subjectPulmonary tuberculosisen_EN
dc.subjectTuberculosis progressionen_EN
dc.subjectFunctional metabolomicsen_EN
dc.subjectMultiplatform metabolomicsen_EN
dc.subjectData fusionen_EN
dc.titleComprehensive Examination of the Mouse Lung Metabolome Following Mycobacterium tuberculosis Infection Using a Multiplatform Mass Spectrometry Approachen_EN
dc.typeArtículoes_ES
dc.identifier.doi10.1021/acs.jproteome.9b00868-
dc.relation.projectIDFunding from the Spanish Ministry of Economy and Competitiveness (RTI2018- 095166-B-I00). M.F-G. acknowledges Fundación Universitaria San Pablo CEU for his Ph.D. fellowship. This work was supported by NIH grants R01Al111940, R61AI138280, R01AI137043 and the Bill and Melinda Gates Foundation award OPP1130017 (AJCS). The research was also co-funded by the South African Medical Research Council (AJCS).-
dc.centroUniversidad San Pablo-CEU-
Aparece en las colecciones: Medicina




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