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Campo DC | Valor | Lengua/Idioma |
---|---|---|
dc.contributor.other | UCH. Departamento de Ciencias Biomédicas | - |
dc.creator | Chen, John | - |
dc.creator | Quiles Puchalt, Nuria | - |
dc.creator | Chiang, Yin Ning | - |
dc.creator | Bacigalupe, Rodrigo | - |
dc.creator | Fillol Salom, Alfred | - |
dc.creator | Chee, Melissa Su Juan | - |
dc.date.accessioned | 2024-01-31T13:05:08Z | - |
dc.date.available | 2024-01-31T13:05:08Z | - |
dc.date.issued | 2018-10-12 | - |
dc.identifier.citation | Chen, J., Quiles-Puchalt, N., Chiang, Y.N., Bacigalupe, R., Fillol-Salom, A., Chee, M.S.J., Fitzgerald, J.R. & Penadés, J.R. (2018). Genome hypermobility by lateral transduction. Science, vol. 362, i. 6411 (oct.), pp. 207–212. DOI: https://doi.org/10.1126/science.aat5867 | es_ES |
dc.identifier.issn | 0036-8075 | - |
dc.identifier.issn | 1095-9203 (Electrónico) | - |
dc.identifier.uri | http://hdl.handle.net/10637/15246 | - |
dc.description | Este recurso no está disponible en acceso abierto por política de la editorial. | - |
dc.description.abstract | Genetic transduction is a major evolutionary force that underlies bacterial adaptation.Here we report that the temperate bacteriophages ofStaphylococcusaureusengage in adistinct form of transduction we term lateral transduction. Staphylococcal prophagesdo not follow the previously described excision-replication-packaging pathway but insteadexcise late in their lytic program. Here, DNA packaging initiates in situ from integratedprophages, and large metameric spans including several hundred kilobases of theS.aureusgenome are packaged in phage heads at very high frequency. In situ replication beforeDNA packaging creates multiple prophage genomes so that lateral-transducing particles formduring normal phage maturation, transforming parts of theS.aureuschromosome intohypermobile regions of gene transfer. | es_ES |
dc.language.iso | en | es_ES |
dc.publisher | American Association for the Advancement of Science | es_ES |
dc.relation | Este artículo de investigación ha sido financiado parcialmente por el Ministerio de Educación del Gobierno de Singapur (T1-2015Sep-13), por el National Medical Research Council (BNIG15may013) y por la National University of Singapore (start-up funds), por el Biotechnology and Biological Sciences Research Council (UK) (BB/I013873/1 y BBS/E/D/20002173), por el Medical Research Council (UK) (MR/M003876/1), por el Biotechnology and Biological Sciences Research Council (BBSRC, UK) (BB/N002873/1), por el ERC-ADG-2014 Proposal n° 670932 Dut-signal (de la EU) y por la Wellcome Trust (201531/Z/16/Z). | - |
dc.relation.ispartof | Science, vol. 362, i. 6411 (oct.) | - |
dc.rights | http://creativecommons.org/licenses/by-nc-nd/4.0/deed.es | - |
dc.subject | Bacteriófagos | es_ES |
dc.subject | Bacteriophages | es_ES |
dc.subject | Célula | es_ES |
dc.subject | Cells | es_ES |
dc.subject | Estafilococos | es_ES |
dc.subject | Staphylococcus | es_ES |
dc.subject | Genética | es_ES |
dc.subject | Genetics | es_ES |
dc.subject | Cromosomas | es_ES |
dc.subject | Chromosomes | es_ES |
dc.subject | Virología | es_ES |
dc.subject | Virology | es_ES |
dc.subject | Biología molecular | es_ES |
dc.subject | Molecular biology | es_ES |
dc.title | Genome hypermobility by lateral transduction | es_ES |
dc.type | Artículo | es_ES |
dc.identifier.doi | https://doi.org/10.1126/science.aat5867 | - |
dc.relation.projectID | T1-2015Sep-13 | - |
dc.relation.projectID | BB/I013873/1 | - |
dc.relation.projectID | BBS/E/D/20002173 | - |
dc.relation.projectID | MR/M003876/1 | - |
dc.relation.projectID | BB/N002873/1 | - |
dc.relation.projectID | 201531/Z/16/Z | - |
dc.centro | Universidad Cardenal Herrera-CEU | - |
Aparece en las colecciones: | Dpto. Ciencias Biomédicas |
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