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Nomenclature of allergic diseases and hypersensitivity reactions: Adapted to modern needs: An EAACI position paper


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Title: Nomenclature of allergic diseases and hypersensitivity reactions: Adapted to modern needs: An EAACI position paper
Authors : Jutel, Marek
Agache, Ioana
Wiacek, Magdalena Zemelka
Akdis, Mubeccel
Chivato Pérez, Tomás
Giacco, Stefano del
Gajdanowicz, Pawel
Eguiluz-Gracia, Ibon
Klimek, Ludger
Lauerma, Antti
Ollert, Markus
O'Mahony, Liam
Schwarze, Jürgen
Shamji, Mohamed
Skypala, Isabel
Palomares, Oscar
Pfaar, Oliver
Torres, María José
Bernstein, Jonathan A.
Cruz, Alvaro A.
Durham, Stephen R.
Galli, Stephen J.
Gómez, R. Maximiliano
Guttman-Yassky, Emma
Haahtela, Tari
Holgate, Stephen T.
Izuhara, Kenji
Kabashima, Kenji
Larenas-Linnemann, Désirée E.
Mutius, Erica von
Nadeau, Kari C.
Pawankar, Ruby
Platts-Mills, Tomas A. E.
Sicherer, Scott H.
Park, Hae-Sim
Vieths, Stefan
Wong, Gary
Zhang, Luo
Bilò, M. Beatrice
Akdis, Cezmi A.
Keywords: Allergic diseasesEAACI position paperHypersensitivityNomenclaturePathophysiologyMechanism
Publisher: Wiley
Citation: Jutel M, Agache I, Zemelka-Wiacek M, et al. Nomenclature of allergic diseases and hypersensitivity reactions: Adapted to modern needs: An EAACI position paper. Allergy. 2023;78:2851-2874. doi:10.1111/all.15889
Abstract: The exponential growth of precision diagnostic tools, including omic technologies, molecular diagnostics, sophisticated genetic and epigenetic editing, imaging and nanotechnologies and patient access to extensive health care, has resulted in vast amounts of unbiased data enabling in-depth disease characterization. New disease endotypes have been identified for various allergic diseases and triggered the gradual transition from a disease description focused on symptoms to identifying biomarkers and intricate pathogenetic and metabolic pathways. Consequently, the current disease taxonomy has to be revised for better categorization. This European Academy of Allergy and Clinical Immunology Position Paper responds to this challenge and provides a modern nomenclature for allergic diseases, which respects the earlier classifications back to the early 20th century. Hypersensitivity reactions originally described by Gell and Coombs have been extended into nine different types comprising antibody- (I-III), cell-mediated (IVa-c), tissue-driven mechanisms (V-VI) and direct response to chemicals (VII). Types I-III are linked to classical and newly described clinical conditions. Type IVa-c are specified and detailed according to the current understanding of T1, T2 and T3 responses. Types V-VI involve epithelial barrier defects and metabolic-induced immune dysregulation, while direct cellular and inflammatory responses to chemicals are covered in type VII. It is notable that several combinations of mixed types may appear in the clinical setting. The clinical relevance of the current approach for allergy practice will be conferred in another article that will follow this year, aiming at showing the relevance in clinical practice where various endotypes can overlap and evolve over the lifetime.
Description: (2024), Correction to: Nomenclature of allergic diseases and hypersensitivity reactions: Adapted to modern needs: An EAACI position paper. Allergy, 79: 269-273. https://doi.org/10.1111/all.15983
URI: http://hdl.handle.net/10637/15197
Rights : http://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
ISSN: 1398-9995
Issue Date: 2023
Center : Universidad San Pablo-CEU
Appears in Collections:Medicina





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