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dc.contributor.otherUCH. Departamento de Ciencias Biomédicas-
dc.contributor.otherUCH. Departamento de Medicina y Cirugía Animal-
dc.creatorGómez Roda, Olga-
dc.creatorBallester Lurbe, Begoña-
dc.creatorPoch Jiménez, Enric-
dc.creatorMesonero, José E.-
dc.creatorTerrado Vicente, José-
dc.date.accessioned2024-01-18T14:54:54Z-
dc.date.available2024-01-18T14:54:54Z-
dc.date.issued2010-11-
dc.identifier.citationGómez, O., Ballester-Lurbe, B., Poch, E., Mesonero, J.E. & Terrado, J. (2010). Developmental regulation of glucose transporters GLUT3, GLUT4 and GLUT8 in the mouse cerebellar cortex. Journal of Anatomy, vol. 217, i. 5 (nov.), pp. 616–623. DOI: https://doi.org/10.1111/j.1469-7580.2010.01291.xes_ES
dc.identifier.issn0021-8782-
dc.identifier.issn1469-7580 (Electrónico)-
dc.identifier.urihttp://hdl.handle.net/10637/14973-
dc.descriptionThis is the peer reviewed version of the following article: Gómez, O., Ballester-Lurbe, B., Poch, E., Mesonero, J.E. & Terrado, J. (2010). Developmental regulation of glucose transporters GLUT3, GLUT4 and GLUT8 in the mouse cerebellar cortex. Journal of Anatomy, vol. 217, i. 5 (nov.), pp. 616–623, which has been published in final form at https://doi.org/10.1111/j.1469-7580.2010.01291.x. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited.-
dc.description.abstractGlucose uptake into the mammalian nervous system is mediated by the family of facilitative glucose transporter proteins (GLUT). In this work we investigate how the expression of the main neuronal glucose transporters (GLUT3, GLUT4 and GLUT8) is modified during cerebellar cortex maturation. Our results reveal that the levels of the three transporters increase during the postnatal development of the cerebellum. GLUT3 localizes in the growing molecular layer and in the internal granule cell layer. However, the external granule cell layer, Purkinje cell cytoplasm and cytoplasm of the other cerebellar cells lack GLUT3 expression. GLUT4 and GLUT8 have partially overlapping patterns, which are detected in the cytoplasm and dendrites of Purkinje cells, and also in the internal granule cell layer where GLUT8 displays a more diffuse pattern. The differential localization of the transporters suggests that they play different roles in the cerebellum, although GLUT4 and GLUT8 could also perform some compensatory or redundant functions. In addition, the increase in the levels and the area expressing the three transporters suggests that these roles become more important as development advances. Interestingly, the external granule cells, which have been shown to express the monocarboxylate transporter MCT2, express none of the three main neuronal GLUTs. However, when these cells migrate inwardly to differentiate in the internal granule cells, they begin to produce GLUT3, GLUT4 and GLUT8, suggesting that the maturation of the cerebellar granule cells involves a switch in their metabolism in such a way that they start using glucose as they mature.es_ES
dc.language.isoenes_ES
dc.publisherJohn Wiley & Sonses_ES
dc.relationEste artículo de investigación ha sido financiado por la Universidad CEU Cardenal Herrera (PRUCH), por el programa de investigación Copernicus-Santander y Fondo de Desarrollo Regional Europeo (FEDER) (SAF 2004–00228). Este grupo de investigación es miembro de Network for Cooperative Research on Membrane Transport Proteins (REIT) y cofinanciado por el Ministerio de Educación y Ciencia del Gobierno de España y por el Fondo de Desarrollo Regional Europeo (BFU2007-30688-E ⁄ BFI).-
dc.relationUCH. Financiación Europea-
dc.relationUCH. Financiación Nacional-
dc.relationUCH. Financiación Universidad-
dc.relation.ispartofJournal of Anatomy, vol. 217, i. 5 (nov.)-
dc.subjectVeterinaria-
dc.subjectVeterinary medicine-
dc.subjectSistema nervioso-
dc.subjectNervous systems-
dc.subjectCélula-
dc.subjectCells-
dc.subjectProteína-
dc.subjectProteins-
dc.titleDevelopmental regulation of glucose transporters GLUT3, GLUT4 and GLUT8 in the mouse cerebellar cortexes_ES
dc.typeArtículoes_ES
dc.description.versionPostprint-
dc.identifier.doihttps://doi.org/10.1111/j.1469-7580.2010.01291.x-
dc.relation.projectIDSAF 2004–00228-
dc.relation.projectIDBFU2007-30688-E ⁄ BFI-
dc.centroUniversidad Cardenal Herrera-CEU-
Aparece en las colecciones: Dpto. Medicina y Cirugía Animal




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