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http://hdl.handle.net/10637/14949
Maternal fructose boosts the effects of a Western-type diet increasing SARS-COV-2 cell entry factors in male offspring
Título : | Maternal fructose boosts the effects of a Western-type diet increasing SARS-COV-2 cell entry factors in male offspring |
Autor : | Fauste Alonso, Elena Donis Rodríguez, Cristina Pérez Armas, Madelín Rodríguez, Lourdes Rodrigo, Silvia Álvarez Millán, Juan José Otero Gómez, Paola Panadero Antón, María Isabel Bocos de Prada, Carlos |
Materias: | Fructose; Fetal programming; SARS-CoV-2; Liver; Ileum; Cholesterol |
Editorial : | Elsevier |
Citación : | Fauste, E., Donis, C., Pérez-Armas, M., Rodríguez, L., Rodrigo, S., Álvarez-Millán, J. J., ... & Bocos, C. (2023). Maternal fructose boosts the effects of a Western-type diet increasing SARS-COV-2 cell entry factors in male offspring. Journal of Functional Foods, 100, 105366. |
Resumen : | Fructose-rich beverages and foods consumption correlates with the epidemic rise in cardiovascular disease, diabetes and obesity. Severity of COVID-19 has been related to these metabolic diseases. Fructose-rich foods could place people at an increased risk for severe COVID-19. We investigated whether maternal fructose intake in offspring affects hepatic and ileal gene expression of proteins that permit SARS-CoV2 entry to the cell. Carbohydrates were supplied to pregnant rats in drinking water. Adult and young male descendants subjected to water, liquid fructose alone or as a part of a Western diet, were studied. Maternal fructose reduced hepatic SARS-CoV2 entry factors expression in older offspring. On the contrary, maternal fructose boosted the Western diet-induced increase in viral entry factors expression in ileum of young descendants. Maternal fructose intake produced a fetal programming that increases hepatic viral protection and, in contrast, exacerbates fructose plus cholesterolinduced diminution in SARS-CoV2 protection in small intestine of progeny. |
URI : | http://hdl.handle.net/10637/14949 |
Derechos: | http://creativecommons.org/licenses/by-nc-nd/4.0/deed.es Open Access |
ISSN : | 2214-9414 |
Fecha de publicación : | ene-2023 |
Centro : | Universidad San Pablo-CEU |
Aparece en las colecciones: | Facultad de Farmacia |
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