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Therapeutic drug monitoring of Erlotinib in non-small cell lung carcinoma: a case study


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Título : Therapeutic drug monitoring of Erlotinib in non-small cell lung carcinoma: a case study
Autor : Catalán Latorre, Ana
Sureda, Manuel
Brugarolas, Antonio
Escudero Ortiz, Vanesa
Materias: Tratamiento médicoMedical treatmentMedicamentoDrugsCáncerCancer
Editorial : Wolters Kluwer
Citación : Catalán-Latorre, A., Sureda, M., Brugarolas-Masllorens, A. & Escudero-Ortiz, V. (2021). Therapeutic drug monitoring of Erlotinib in non-small cell lung carcinoma: a case study. Therapeutic Drug Monitoring, vol. 43, i. 4 (01 aug.), pp. 447–450. DOI: https://doi.org/10.1097/FTD.0000000000000894
Resumen : We describe a clinical case of an 84-year-old man diagnosed with non-small cell lung carcinoma and epidermal growth factor receptor mutation, who was treated with erlotinib, with doses adjusted by therapeutic drug monitoring. This case involved a clearance fluctuation leading to over-therapeutic drug concentrations of erlotinib and toxicity. The intrapatient and interpatient variability of erlotinib, in addition to other factors such as age or variations in liver clearance, create situations that are challenging in clinical practice. During treatment, erlotinib serum concentrations were measured, and the dose was accordingly adjusted. The erlotinib dose required to reduce toxicity (rash grade III) and maintain effective plasma concentrations, as well as clinical and radiological responses, was 50% of the initial dose, underscoring the relevance of therapeutic drug monitoring for tyrosine kinase inhibitors in routine clinical practice.
Descripción : Este recurso no está disponible en acceso abierto por política de la editorial.
URI : http://hdl.handle.net/10637/14892
Derechos: http://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
ISSN : 0163-4356
1536-3694 (Electrónico)
Fecha de publicación : 1-ago-2021
Centro : Universidad Cardenal Herrera-CEU
Aparece en las colecciones: Dpto. Ciencias Biomédicas





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