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Arterial stiffness is associated with adipokine dysregulation in non-hypertensive obese mice

Título : Arterial stiffness is associated with adipokine dysregulation in non-hypertensive obese mice
Autor : Gil Ortega, Marta
Martín Ramos, Miriam
González, María del Carmen
Aránguez, Isabel
Ruíz Gayo, Mariano
Somoza Hernández, Beatriz
Fernández Alfonso, María Soledad
Materias: Diet-induced obesityArterial remodelingOxidative stress
Editorial : Elsevier
Citación : Gil-Ortega M, Martín-Ramos M, Arribas SM, González MC, Aránguez I, Ruiz-Gayo M, Somoza B, Fernández-Alfonso MS. Arterial stiffness is associated with adipokine dysregulation in non-hypertensive obese mice. Vascul Pharmacol. 2016 Feb;77:38-47. doi: 10.1016/j.vph.2015.05.012.
Resumen : The aim of this study was to characterize alterations in vascular structure and mechanics in murine mesenteric arteries from obese non-hypertensive mice, as well as their relationship with adipokines. Four-week old C57BL/6J male mice were assigned either to a control (C, 10% kcal from fat) or a high-fat diet (HFD, 45% kcal from fat) for 32 weeks. HFD animals weighed 30% more than controls (p b 0.001), exhibited similar blood pressure, increased leptin, insulin and superoxide anion (O2 •−) levels, and reduced adiponectin levels and nitric oxide (NO) bioavailability. Arterial structure showed an outward remodeling with an increase in total number of both adventitial and smoothmuscle cells inHFD.Moreover, HFDmice exhibited an increased arterial stiffness assessed by β-values (C=2.4±0.5 vs HFD=5.3±0.8; p b 0.05) and aortic pulse wave velocity (PWV, C=3.4±0.1 vs HFD = 3.9 ± 0.1; p b 0.05). β-Values and PWV positively correlated with leptin, insulin or O2 •− levels, whereas they negatively correlated with adiponectin levels and NO bioavailability (p b 0.01). A reduction in fenestrae number together with an increase in type-I collagen amount (p b 0.05) were observed in HFD. These data demonstrate that HFD accounts for the development of vascular remodeling and arterial stiffness associated with adipokine dysregulation and oxidative stress, independently of hypertension development.
URI : http://hdl.handle.net/10637/14609
Derechos: http://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
OpenAccess
ISSN : 1537-1891
Fecha de publicación : 28-feb-2016
Centro : Universidad San Pablo-CEU
Aparece en las colecciones: Facultad de Farmacia





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