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Differential Deleterious Impact of Highly Saturated Versus Monounsaturated Fat Intake on Vascular Function, Structure, and Mechanics in Mice

Título : Differential Deleterious Impact of Highly Saturated Versus Monounsaturated Fat Intake on Vascular Function, Structure, and Mechanics in Mice
Autor : Gil Ortega, Marta
Ruíz Gayo, Mariano
Fernández Felipe, Jesús
González Blázquez, Raquel
Olmo Izquierdo, Nuria del
Somoza Hernández, Beatriz
Materias: Endothelial dysfunctionVascular remodeling
Editorial : MDPI
Citación : Vega-Martín, E.; Gil-Ortega, M.; González-Blázquez, R.; Benedito, S.; Fernández-Felipe, J.; Ruiz-Gayo, M.; del Olmo, N.; Chowen, J.A.; Frago, L.M.; Somoza, B.; et al. Differential Deleterious Impact of Highly Saturated Versus Monounsaturated Fat Intake on Vascular Function, Structure, and Mechanics in Mice. Nutrients 2021, 13, 1003. https://doi.org/10.3390/ nu13031003
Resumen : Vegetable oils such as palm oil (enriched in saturated fatty acids, SFA) and high-oleic-acid sunflower oil (HOSO, containing mainly monounsaturated fatty acids, MUFA) have emerged as the most common replacements for trans-fats in the food industry. The aim of this study is to analyze the impact of SFA and MUFA-enriched high-fat (HF) diets on endothelial function, vascular remodeling, and arterial stiffness compared to commercial HF diets. Five-week-old male C57BL6J mice were fed a standard (SD), a HF diet enriched with SFA (saturated oil-enriched Food, SOLF), a HF diet enriched with MUFA (unsaturated oil-enriched Food, UOLF), or a commercial HF diet for 8 weeks. Vascular function was analyzed in the thoracic aorta. Structural and mechanical parameters were assessed in mesenteric arteries by pressure myography. SOLF, UOLF, and HF diet reduced contractile responses to phenylephrine and induced endothelial dysfunction in the thoracic aorta. A significant increase in the -index, and thus in arterial stiffness, was also detected in mesenteric arteries from the three HF groups, due to enhanced deposition of collagen in the vascular wall. SOLF also induced hypotrophic inward remodeling. In conclusion, these data demonstrate a deleterious effect of HF feeding on obesity-related vascular alterations that is exacerbated by SFA.
Descripción : En colaboración con: Elena Vega-Martín, Sara Benedito, Julie A. Chowen, Laura M. Frago and María S. Fernández-Alfonso
URI : http://hdl.handle.net/10637/14608
Derechos: http://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
OpenAccess
ISSN : 2072-6643
Fecha de publicación : 19-mar-2021
Centro : Universidad San Pablo-CEU
Aparece en las colecciones: Facultad de Farmacia





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