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Mechanisms of Perivascular Adipose Tissue Dysfunction in Obesity

Título : Mechanisms of Perivascular Adipose Tissue Dysfunction in Obesity
Autor : Gil Ortega, Marta
García Prieto, Concepción F.
Ruíz Gayo, Mariano
Somoza Hernández, Beatriz
Materias: Blood vesselsVasculatureNoradrenaline
Editorial : Hindawi
Citación : Fernández-Alfonso MS, Gil-Ortega M, García-Prieto CF, Aranguez I, Ruiz-Gayo M, Somoza B. Mechanisms of perivascular adipose tissue dysfunction in obesity. Int J Endocrinol. 2013;2013:402053. doi: 10.1155/2013/402053
Resumen : Most blood vessels are surrounded by adipose tissue. Similarly to the adventitia, perivascular adipose tissue (PVAT) was considered only as a passive structural support for the vasculature, and it was routinely removed for isolated blood vessel studies. In 1991, Soltis and Cassis demonstrated for the first time that PVAT reduced contractions to noradrenaline in rat aorta. Since then, an important number of adipocyte-derived factors with physiological and pathophysiological paracrine vasoactive effects have been identified. PVAT undergoes structural and functional changes in obesity. During early diet-induced obesity, an adaptative overproduction of vasodilator factors occurs in PVAT, probably aimed at protecting vascular function. However, in established obesity, PVAT loses its anticontractile properties by an increase of contractile, oxidative, and inflammatory factors, leading to endothelial dysfunction and vascular disease.The aim of this review is to focus on PVAT dysfunction mechanisms in obesity
Descripción : En colaboración con: Maria S. Fernández-Alfonso e Isabel Aranguez
URI : http://hdl.handle.net/10637/14607
Derechos: http://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
OpenAccess
ISSN : 1687-8345
Fecha de publicación : 7-nov-2013
Centro : Universidad San Pablo-CEU
Aparece en las colecciones: Facultad de Farmacia





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