Please use this identifier to cite or link to this item:
http://hdl.handle.net/10637/14504
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.other | Universidad San Pablo-CEU. Facultad de Farmacia. Departamento de Química y Bioquímica | - |
dc.contributor.other | Grupo de Metabolismo y Función Vascular (MET-VASC) | - |
dc.creator | Alcalá Díaz-Mor, Martín | - |
dc.creator | Calderón Domínguez, María | - |
dc.creator | Bustos, Eduviges | - |
dc.creator | Ramos, Dolores | - |
dc.creator | Viana Arribas, Marta | - |
dc.creator | Herrero, Laura | - |
dc.date | 2017 | - |
dc.date.accessioned | 2023-07-05T04:00:45Z | - |
dc.date.available | 2023-07-05T04:00:45Z | - |
dc.date.issued | 2017-11-22 | - |
dc.identifier | 000000740434 | - |
dc.identifier.citation | Alcalá M, Calderon-Dominguez M, Bustos E, Ramos P, Casals N, Serra D, Viana M, Herrero L. Increased inflammation, oxidative stress and mitochondrial respiration in brown adipose tissue from obese mice. Sci Rep. 2017 Nov 22;7(1):16082. doi: 10.1038/s41598-017-16463-6. | - |
dc.identifier.uri | http://hdl.handle.net/10637/14504 | - |
dc.description.abstract | Obesity is associated with severe metabolic diseases such as type 2 diabetes, insulin resistance, cardiovascular disease and some forms of cancer. The pathophysiology of obesity-induced metabolic diseases has been strongly related to white adipose tissue (WAT) dysfunction through several mechanisms such as fibrosis, apoptosis, inflammation, ER and oxidative stress. However, little is known of whether these processes are also present in brown adipose tissue (BAT) during obesity, and the potential consequences on mitochondrial activity. Here we characterized the BAT of obese and hyperglycemic mice treated with a high-fat diet (HFD) for 20 weeks. The hypertrophic BAT from obese mice showed no signs of fibrosis nor apoptosis, but higher levels of inflammation, ER stress, ROS generation and antioxidant enzyme activity than the lean counterparts. The response was attenuated compared with obesity-induced WAT derangements, which suggests that BAT is more resistant to the obesity-induced insult. In fact, mitochondrial respiration in BAT from obese mice was enhanced, with a 2-fold increase in basal oxygen consumption, through the upregulation of complex III of the electron transport chain and UCP1. Altogether, our results show that obesity is accompanied by an increase in BAT mitochondrial activity, inflammation and oxidative damage. | en_EN |
dc.format | application/pdf | - |
dc.language.iso | en | - |
dc.publisher | Nature | - |
dc.relation.ispartof | Scientific Reports | - |
dc.rights | http://creativecommons.org/licenses/by-nc-nd/4.0/deed.es | - |
dc.rights | openAccess | - |
dc.subject | Obesity | en_EN |
dc.subject | Metabolic diseases | en_EN |
dc.title | Increased inflammation, oxidative stress and mitochondrial respiration in brown adipose tissue from obese mice | en_EN |
dc.type | Artículo | - |
dc.identifier.doi | 10.1038/s41598-017-16463-6 | - |
dc.relation.projectID | SAF2013-45887 | - |
dc.relation.projectID | SAF2014-56671R | - |
dc.relation.projectID | SAF2014-52223-C2-1-R | - |
dc.relation.projectID | SAF2014-52223-C2-2-R | - |
dc.relation.projectID | CIBEROBN Grant CB06/03/0001 | - |
dc.centro | Universidad San Pablo-CEU | - |
Appears in Collections: | Facultad de Farmacia |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.