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Molecular management of high-grade serous ovarian carcinoma


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Título : Molecular management of high-grade serous ovarian carcinoma
Autor : Punzón Jiménez, Paula
Lago Leal, Víctor
Domingo del Pozo, Santiago
Simón Vallés, Carlos
Mas Perucho, Aymara
Materias: Ovarios - Biopsia.Ovaries - Cancer - Diagnosis.Tumor markers.Ovaries - Biopsy.Marcadores tumorales.Ovarios - Cáncer - Diagnóstico.
Editorial : MDPI
Citación : Punzón-Jiménez, P., Lago, V., Domingo, S., Simón, C. & Mas, A. (2022). Molecular management of high-grade serous ovarian carcinoma. International Journal of Molecular Sciences, vol. 23, i. 22 (09 nov.), art. 13777. DOI: https://doi.org/10.3390/ijms232213777
Resumen : High-grade serous ovarian carcinoma (HGSOC) represents the most common form of epithelial ovarian carcinoma. The absence of specific symptoms leads to late-stage diagnosis, making HGSOC one of the gynecological cancers with the worst prognosis. The cellular origin of HGSOC and the role of reproductive hormones, genetic traits (such as alterations in P53 and DNA-repair mechanisms), chromosomal instability, or dysregulation of crucial signaling pathways have been considered when evaluating prognosis and response to therapy in HGSOC patients. However, the detection of HGSOC is still based on traditional methods such as carbohydrate antigen 125 (CA125) detection and ultrasound, and the combined use of these methods has yet to support significant reductions in overall mortality rates. The current paradigm for HGSOC management has moved towards early diagnosis via the non-invasive detection of molecular markers through liquid biopsies. This review presents an integrated view of the relevant cellular and molecular aspects involved in the etiopathogenesis of HGSOC and brings together studies that consider new horizons for the possible early detection of this gynecological cancer.
Descripción : Este artículo se encuentra disponible en la siguiente URL: https://www.mdpi.com/1422-0067/23/22/13777
Este artículo de investigación pertenece al número especial "Molecular Advances in Cancer Genetics 2.0".
URI : http://hdl.handle.net/10637/14410
Derechos: http://creativecommons.org/licenses/by/4.0/deed.es
ISSN : 1422-0067 (Electrónico)
Idioma: es
Fecha de publicación : 9-nov-2022
Centro : Universidad Cardenal Herrera-CEU
Aparece en las colecciones: Dpto. Medicina y Cirugía





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