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http://hdl.handle.net/10637/14267
Immunological profile of two canine breeds in an endemic region of "Leishmania infantum"
Title: | Immunological profile of two canine breeds in an endemic region of "Leishmania infantum" |
Authors : | Macià, Maria Marín García, Pablo Jesús Ahuir Baraja, Ana Elena Llobat Bordes, Lola |
Keywords: | Perros - Enfermedades infecciosas.; Dog breeds.; Zoonosis.; Zoonoses.; Leishmaniasis en los perros - Aspectos inmunológicos.; Leishmaniasis in dogs - Immunological aspects.; Dogs - Communicable diseases.; Perros - Razas. |
Publisher: | Elsevier |
Citation: | Macià, M., Marín-García, P. J., Ahuir-Baraja, A. E. & Llobat, L. (2023). Immunological profile of two canine breeds in an endemic region of Leishmania infantum. Veterinary Parasitology: Regional Studies and Reports, vol. 40, art. 100861 (may.). DOI: https://doi.org/10.1016/j.vprsr.2023.100861 |
Abstract: | Visceral leishmaniosis is the one of the most important protozoal zoonoses in Europe, and it is caused by Leishmania infantum, an intracellular protozoan parasite. The disease is endemic in dogs in the Mediterranean area. The main goal of this work is to correlate the levels of several cytokines linked to immune response against L. infantum infection in two canine breeds. Thirty-one Boxer and twenty-eight Ibizan Hound dogs living in the Valencian Community (East coast of Spain) were analyzed for the presence of anti-Leishmania antibodies in serum by IFAT test. Cytokines IFN-γ, TNF-α, IL-2, IL-6, IL-8, and IL-18 were determined by ELISA commercial tests. The levels of IFN-γ, IL-2, and IL-18 in our study, cytokines linked to a cellular immune response, were higher (p < 0.05) in the Ibizan Hound breed; IL-6 levels were higher, although not significant, and only levels of IL-8 were higher in Boxer than in Ibizan Hound. No expression of TNF-α was found. These results corroborate that Ibizan Hound can develop a protective response against canine leishmaniosis, while Boxer is a susceptible breed. The study of immunological aspects in the different canine breeds may represent a useful tool in the prediction of the disease. |
Description: | Este artículo se encuentra disponible en la siguiente URL: https://www.sciencedirect.com/science/article/pii/S240593902300031X?via%3Dihub |
URI: | http://hdl.handle.net/10637/14267 |
Rights : | http://creativecommons.org/licenses/by-nc-nd/4.0/deed.es |
ISSN: | 2405-9390 (Electrónico) |
Language: | es |
Supported by: | Acuerdo Transformativo - 2023 |
Issue Date: | 13-May-2023 |
Center : | Universidad Cardenal Herrera-CEU |
Appears in Collections: | Dpto. Producción y Sanidad Animal, Salud Pública Veterinaria y Ciencia y Tecnología de los Alimentos |
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