Por favor, use este identificador para citar o enlazar este ítem: http://hdl.handle.net/10637/14161
Registro completo de metadatos
Campo DC Valor Lengua/Idioma
dc.contributor.otherProducción Científica UCH 2022-
dc.contributor.otherUCH. Departamento de Farmacia-
dc.contributor.otherUCH. Departamento de Ciencias Biomédicas-
dc.contributor.otherUCH. Departamento de Medicina y Cirugía-
dc.creatorCardells Peris, María-
dc.creatorMartinez Albiñana, Alba-
dc.creatorPascual Ortiz, Marina-
dc.creatorSheth Shah, Chirag Chandrakant-
dc.creatorVeses Jiménez, Verónica.-
dc.date2022-
dc.date.accessioned2023-03-15T05:01:00Z-
dc.date.available2023-03-15T05:01:00Z-
dc.date.issued2022-02-11-
dc.identifier.citationPeris, M. C., Martínez, A., Ortíz, M. P., Sheth, C. C. & Veses, V. (2022). Icariin in combination with Amoxycillin-Clavulanate and Ampicillin, but not Vancomycin, increases antibiotic sensitivity and growth inhibition against Methicillin-resistant "Staphylococcus aureus". Antibiotics, vol. 11, i. 2 (11 feb.), art. 233. DOI: https://doi.org/10.3390/antibiotics11020233-
dc.identifier.issn2079-6382 (Electrónico)-
dc.identifier.urihttp://hdl.handle.net/10637/14161-
dc.descriptionEste artículo se encuentra disponible en la siguiente URL: https://www.mdpi.com/2079-6382/11/2/233-
dc.descriptionEste artículo de investigación pertenece al número especial "Phytocompounds with Antimicrobial Activity: From Discovery to Application".-
dc.description.abstractThe widespread irrational use of antibiotics in recent years has resulted in an increase in the detection of multi-resistant bacterial strains, particularly methicillin-resistant Staphylococcus aureus (MRSA). The use of natural derivatives such as flavonoids is postulated as one of the most promising avenues to solve this emerging public health problem. The objective of the present study is to characterize the antimicrobial activity of icariin, a flavonoid compound isolated from a variety of plants of the Epimedium genus, against human and animal clinical MRSA isolates. Our study found that icariin alone did not have any antimicrobial effect on S. aureus or MRSA clinical isolates. However, icariin enhanced the effect of amoxycillin-clavulanate or ampicillin, whereas no effect was seen when used in combination with vancomycin. Specifically, co-incubation of S. aureus with amoxycillin-clavulanate plus icariin resulted in an increased proportion of dead cells, suggesting that this flavonoid potentially increases antimicrobial activity when used in combination with the beta-lactam antibiotic amoxycillin-clavulanate. Furthermore, we demonstrate that co-incubation of S. aureus with AmoxyClav plus icariin resulted in increased membrane disruption and growth inhibition. This study demonstrates the potential utility of icariin in permitting lower antibiotic therapeutic doses in alignment with strategies to reduce the spread of antibiotic resistance. Further research is required to determine the optimum concentration of icariin and to define clinically relevant combinations of flavonoid and antibiotic.-
dc.formatapplication/pdf-
dc.languagees-
dc.language.isoen-
dc.publisherMDPI-
dc.relationEste artículo de investigación ha sido financiado por la Universidad CEU Cardenal Herrera (INDI21/59 y INDI20/52).-
dc.relationUCH. Financiación Universidad-
dc.relation.ispartofAntibiotics, vol. 11, i. 2 (11 feb. 2022)-
dc.rightshttp://creativecommons.org/licenses/by/4.0/deed.es-
dc.subjectFlavonoids - Therapeutic use.-
dc.subjectEstafilococos - Resistencia a los medicamentos.-
dc.subjectFlavonoides - Uso terapéutico.-
dc.subjectAntibióticos.-
dc.subjectIcariin - Therapeutic use.-
dc.subjectIcariin - Uso terapéutico.-
dc.subjectBacterias - Resistencia a los medicamentos.-
dc.subjectDrug resistance in bacteria.-
dc.subjectDrug resistance in Staphylococcus.-
dc.subjectAntibiotics.-
dc.titleIcariin in combination with amoxycillin-clavulanate and ampicillin, but not vancomycin, increases antibiotic sensitivity and growth inhibition against methicillin-resistant "Staphylococcus aureus"-
dc.typeArtículo-
dc.identifier.doihttps://doi.org/10.3390/antibiotics11020233-
dc.relation.projectIDINDI21/59-
dc.relation.projectIDINDI20/52-
dc.centroUniversidad Cardenal Herrera-CEU-
Aparece en las colecciones: Dpto. Ciencias Biomédicas




Los ítems de DSpace están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.