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dc.contributor.otherProducción Científica UCH 2021-
dc.contributor.otherUCH. Departamento de Medicina y Cirugía-
dc.creatorSanchis Artero, Laura-
dc.creatorMartínez Blanch, Juan Francisco-
dc.creatorManresa Vera, Sergio-
dc.creatorCortés Castell, Ernesto-
dc.creatorValls Gandia, Marina-
dc.creatorIborra, Marisa-
dc.creatorCortés Rizo, Xavier-
dc.date2021-
dc.date.accessioned2022-05-04T04:00:20Z-
dc.date.available2022-05-04T04:00:20Z-
dc.date.issued2021-05-11-
dc.identifier.citationSanchis-Artero, L., Martínez-Blanch, J.F., Manresa-Vera, S., Cortés-Castell, E., Valls-Gandia, M., Iborra, M. et al. (2021). Evaluation of changes in intestinal microbiota in Crohn’s disease patients after anti-TNF alpha treatment. Scientific Reports, vol. 11, art. 10016 (11 may.). DOI: https://doi.org/10.1038/s41598-021-88823-2-
dc.identifier.issn2045-2322 (Electrónico)-
dc.identifier.urihttp://hdl.handle.net/10637/13696-
dc.descriptionEste artículo se encuentra disponible en la siguiente URL: https://www.nature.com/articles/s41598-021-88823-2.pdf-
dc.descriptionEn este artículo también participan: Jose Maria Paredes-Arquiola, Maia Boscá-Watts, Jose Maria Huguet, Rafael Gil-Borrás y Josefa Rodríguez-Morales.-
dc.description.abstractIntestinal dysbiosis is key in the onset and development of Crohn’s disease (CD). We evaluated the microbiota changes in CD patients before and after a six-month anti-TNF treatment, comparing these changes with the microbiota of healthy subjects. This prospective multicenter observational study involved 27 CD patients initiating anti-TNF treatment and 16 healthy individuals. Inflammatory activity was determined at baseline, 3 and 6 months, classifying patients into responders and nonresponders. Fecal microbiota was analyzed by massive genomic sequencing thought 16S rRNA amplicon sequencing before and after six months of anti-TNF treatment. The CD cohort showed a decrease in genera of the class Clostridia, short-chain fatty acid producers, and an increase in the phylum Proteobacteria (p < 0.01) versus the healthy cohort. After anti-TNF treatment, the phylum Proteobacteria also increased in non-responders versus responders (13/27) (p < 0.005), with the class Clostridia increasing. In addition, alpha diversity increased in responders versus non-responders (p < 0.01), tending towards eubiosis. An association was found (p < 0.001) in the F.prausnitzii/E.coli ratio between responders and non-responders. The F/E ratio was the most accurate biomarker of anti-TNF response (area under the curve 0.87). Thus, anti-TNF treatment allows partial restoration of intestinal microbiota in responders and the F.prausnitzii/E.coli ratio can provide a reliable indicator of response to anti-TNF in CD.-
dc.formatapplication/pdf-
dc.language.isoen-
dc.language.isoes-
dc.publisherNature Research-
dc.relation.ispartofScientific Reports, vol. 11 (11 may. 2021)-
dc.rightshttp://creativecommons.org/licenses/by/4.0/deed.es-
dc.subjectGastroenterología.-
dc.subjectGastroenterology.-
dc.subjectDigestive organs - Diseases.-
dc.subjectCrohn's disease - Microbiology.-
dc.subjectAparato digestivo - Enfermedades.-
dc.subjectCrohn, Enfermedad de - Microbiología.-
dc.titleEvaluation of changes in intestinal microbiota in Crohn's disease patients after anti-TNF alpha treatment-
dc.typeArtículo-
dc.identifier.doihttps://doi.org/10.1038/s41598-021-88823-2-
dc.centroUniversidad Cardenal Herrera-CEU-
Aparece en las colecciones: Dpto. Medicina y Cirugía




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