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Lateral transduction is inherent to the life cycle of the archetypical "Salmonella" phage P22


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Título : Lateral transduction is inherent to the life cycle of the archetypical "Salmonella" phage P22
Autor : Fillol Salom, Alfred
Bacigalupe, Rodrigo
Humphrey, Suzanne
Chiang, Yin Ning
Chen, John
Penadés Casanova, José Rafael
Materias: ADN - Replicación.Bacteriófagos.Genetics.DNA replication.Genética.Bacteriophages.
Editorial : Springer Nature
Citación : Fillol-Salom, A., Bacigalupe, R., Humphrey, S., Chiang, Y. N., Chen, J. & Penadés, J.R. (2021). Lateral transduction is inherent to the life cycle of the archetypical Salmonella phage P22. Nature Communications, vol. 12 (08 nov.), art. 6510. DOI: https://doi.org/10.1038/s41467-021-26520-4
Resumen : Lysogenic induction ends the stable association between a bacteriophage and its host, and the transition to the lytic cycle begins with early prophage excision followed by DNA replication and packaging (ERP). This temporal program is considered universal for P22-like temperate phages, though there is no direct evidence to support the timing and sequence of these events. Here we report that the long-standing ERP program is an observation of the experimentally favored Salmonella phage P22 tsc229 heat-inducible mutant, and that wildtype P22 actually follows the replication-packaging-excision (RPE) program. We find that P22 tsc229 excises early after induction, but P22 delays excision to just before it is detrimental to phage production. This allows P22 to engage in lateral transduction. Thus, at minimal expense to itself, P22 has tuned the timing of excision to balance propagation with lateral transduction, powering the evolution of its host through gene transfer in the interest of selfpreservation.
Descripción : Este artículo se encuentra disponible en la página web de la revista en la siguiente URL: https://www.nature.com/articles/s41467-021-26520-4.pdf
URI : http://hdl.handle.net/10637/13677
Derechos: http://creativecommons.org/licenses/by/4.0/deed.es
ISSN : 2041-1723 (Electrónico)
Fecha de publicación : 8-nov-2021
Centro : Universidad Cardenal Herrera-CEU
Aparece en las colecciones: Dpto. Ciencias Biomédicas





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