Por favor, use este identificador para citar o enlazar este ítem: http://hdl.handle.net/10637/13633
Registro completo de metadatos
Campo DC Valor Lengua/Idioma
dc.contributor.otherProducción Científica UCH 2021-
dc.contributor.otherUCH. Departamento de Ciencias Biomédicas-
dc.creatorMata Roig, Manuel-
dc.creatorZurriaga Carda, Javier-
dc.creatorMilian Medina, Lara-
dc.creatorReula Martín, Ana-
dc.creatorArmengot, Miguel-
dc.creatorRuiz Saurí, Amparo-
dc.creatorCarda Batalla, Carmen-
dc.date2021-
dc.date.accessioned2022-04-07T04:00:34Z-
dc.date.available2022-04-07T04:00:34Z-
dc.date.issued2021-02-11-
dc.identifier.citationMata, M., Zurriaga, J., Milian, L., Reula, A., Armengot, M., Ruiz-Sauri, A. & Carda, C. (2021). IFT46 expression in the nasal mucosa of Primary Ciliary Dyskinesia patients: preliminary study. Allergy & Rhinology, vol. 12, art. 2152656721989288 (11 feb.). DOI: https://doi.org/10.1177/2152656721989288-
dc.identifier.issn2152-6575-
dc.identifier.issn2152-6567 (Electrónico)-
dc.identifier.urihttp://hdl.handle.net/10637/13633-
dc.descriptionEste artículo se encuentra disponible en la siguiente URL: https://journals.sagepub.com/doi/pdf/10.1177/2152656721989288-
dc.description.abstractBackground: Primary ciliary dyskinesia (PCD) is characterised by an imbalance in mucociliary clearance leading to chronic respiratory infections. Cilia length is considered to be a contributing factor in cilia movement. Recently, IFT46 protein has been related to cilia length. Therefore, this work aims to study IFT46 expression in a PCD patients cohort and analyse its relationship with cilia length and function, as it was not previously described. Materials and methods: The expression of one intraflagellar transport (IFT46) and two regulating ciliary architecture (FOXJ1 and DNAI2) genes, as well as cilia length of 27 PCD patients, were measured. PCD patients were diagnosed based on clinical data, and cilia function and ultrastructure. Gene expression was estimated by real-time RT-PCR and cilia length by electron microscopy in nasal epithelium biopsies. Results and conclusions: While IFT46 expression was only diminished in patients with short cilia, FOXJ1, and DNAI2 expression were reduced in all PCD patient groups compared to controls levels. Among the PCD patients, cilia were short in 44% (5.9 0.70 mm); nine of these (33% from the total) patients’ cilia also had an abnormal ultrastructure. Cilia length was normal in 33% of patients (6.4 0.39 mm), and only three patients’ biopsies indicated decreased expression of dynein.-
dc.formatapplication/pdf-
dc.language.isoen-
dc.language.isoes-
dc.publisherSAGE-
dc.relationEste trabajo de investigación fue financiado por el Ministerio de Economía y Competitividad (MINECO) y por el Instituto de Salud Carlos III (PI16-01315 y PID2019-106099RB-C42) del Gobierno de España (MM). CIBER-BBN y CIBERER están financiados por el VI Plan Nacional de I+D+i 2008-2011, Iniciativa Ingenio 2010, Programa Consolider, Acciones CIBER y el Instituto de Salud Carlos III, con ayuda del Fondo Europeo de Desarrollo Regional (FEDER).-
dc.relationUCH. Financiación Nacional-
dc.relationUCH. Financiación Europea-
dc.relation.ispartofAllergy & Rhinology, vol. 12-
dc.rightshttp://creativecommons.org/licenses/by-nc/4.0/deed.es-
dc.subjectEnfermedades crónicas.-
dc.subjectRespiratory organs - Diseases.-
dc.subjectOtolaryngology.-
dc.subjectOtorrinolaringología.-
dc.subjectDisquinesia ciliar, Síndrome de - Aspectos genéticos.-
dc.subjectAparato respiratorio - Enfermedades.-
dc.subjectChronic diseases.-
dc.subjectKartagener, Síndrome de - Aspectos genéticos.-
dc.subjectPrimary ciliary dyskinesia - Genetic aspects.-
dc.subjectKartagener's syndrome - Genetic aspects.-
dc.titleIFT46 expression in the nasal mucosa of Primary Ciliary Dyskinesia patients : preliminary study-
dc.typeArtículo-
dc.identifier.doihttps://doi.org/10.1177/2152656721989288-
dc.relation.projectIDPI16-01315-
dc.relation.projectIDPID2019-106099RB-C42-
dc.centroUniversidad Cardenal Herrera-CEU-
Aparece en las colecciones: Dpto. Ciencias Biomédicas




Los ítems de DSpace están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.