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dc.contributor.otherUniversidad San Pablo-CEU. Facultad de Farmacia. Departamento de Química y Bioquímica-
dc.creatorRodríguez, Lourdes-
dc.creatorBocos de Prada, Carlos-
dc.creatorRodrigo, Silvia-
dc.creatorFauste Alonso, Elena-
dc.creatorPanadero Antón, María Isabel-
dc.date2020-
dc.date.accessioned2021-08-10T04:00:13Z-
dc.date.available2021-08-10T04:00:13Z-
dc.date.issued2020-08-10-
dc.identifier000000723166-
dc.identifier.urihttp://hdl.handle.net/10637/12943-
dc.descriptionEn: Molecular Nutrition Food Research. 2020. vol. 64 : 2000628. e-ISSN 1613-4133-
dc.description.abstractScope : Fructose intake from added sugars correlates with the epidemic rise in metabolic syndrome and cardiovascular diseases. However, consumption of beverages containing fructose is allowed during gestation. Homocysteine (Hcy) is a well-known risk factor for cardiovascular diseases while hydrogen sulfide (H2S), a product of its metabolism, has been proved to exert opposite effects to Hcy. Methods and results : First, we investigated whether maternal fructose intake produces subsequent changes in Hcy metabolism and H2S synthesis of the progeny. Carbohydrates were supplied to pregnant rats in drinking water (10% wt/vol) throughout gestation. Adult female descendants from fructosefed, control or glucose-fed mothers were studied. Females from fructose-fed mothers had elevated homocysteinemia, hepatic H2S production, cystathionine -lyase (CSE) (the key enzyme in H2S synthesis) expression and plasma H2S, versus the other two groups. Second, we studied how adult female progeny from control (C/F), fructose- (F/F) and glucose-fed (G/F) mothers responded to liquid fructose and compared them to the control group (C/C). Interestingly, both hepatic CSE expression and H2S synthesis were diminished by fructose intake, this effect being more pronounced in F/F females. Conclusions : Maternal fructose intake produces a fetal programming that increases hepatic H2S production and, in contrast, exacerbates its fructose-induced drop in female progeny.en-EN
dc.formatapplication/pdf-
dc.language.isoen-
dc.publisherWiley-
dc.relation.ispartofMolecular Nutrition Food Research-
dc.rightshttp://creativecommons.org/licenses/by-nc-nd/4.0/deed.es-
dc.subjectFructose.en-EN
dc.subjectFetal programming.en-EN
dc.subjectH2S.en-EN
dc.subjectLiver.en-EN
dc.subjectOxidative stress.en-EN
dc.titleMaternal fructose intake increases liver H2S synthesis but exarcebates its fructose-induced decrease in female progeny.-
dc.typeArtículo-
dc.identifier.doi10.1002/mnfr.202000628-
dc.relation.projectIDMinisterio de Ciencia, Innovación y Universidades (MICINN) (SAF2017-89537-R)-
dc.relation.projectIDEuropean Community FEDER funds-
dc.centroUniversidad San Pablo-CEU-
Aparece en las colecciones: Facultad de Farmacia




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