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dc.contributor.otherUCH. Departamento de Producción y Sanidad Animal, Salud Pública Veterinaria y Ciencia y Tecnología de los Alimentos-
dc.contributor.otherProducción Científica UCH 2019-
dc.creatorAlmendros, Isaac-
dc.creatorMartínez Ros, Paula-
dc.creatorFarré López, Nuria-
dc.creatorRubio Zaragoza, Mónica.-
dc.creatorTorres Torrillas, Marta-
dc.creatorGutiérrez Bautista, Álvaro Jesús-
dc.creatorCarrillo Poveda, José María.-
dc.creatorSopena Juncosa, Joaquín Jesús.-
dc.creatorGozal, David-
dc.creatorGonzález de Bulnes López, Antonio-
dc.creatorFarré, Ramon-
dc.date2019-
dc.date.accessioned2020-12-12T05:00:12Z-
dc.date.available2020-12-12T05:00:12Z-
dc.date.issued2019-09-01-
dc.identifier.citationAlmendros, I., Martínez-Ros, P., Farré, N., Rubio-Zaragoza, M., Torres, M., Gutiérrez-Bautista. ÁJ. et al. (2019). Placental oxygen transfer reduces hypoxia-reoxygenation swings in fetal blood in a sheep model of gestational sleep apnea. Journal of Applied Physiology (1985), vol. 127, i. 3 (sep.), pp. 745-752. DOI: https://doi.org/10.1152/japplphysiol.00303.2019-
dc.identifier.issn8750-7587-
dc.identifier.issn1522-1601 (Electrónico)-
dc.identifier.urihttp://hdl.handle.net/10637/11753-
dc.descriptionEste artículo se encuentra disponible en la página web de la revista en la siguiente URL: https://journals.physiology.org/doi/full/10.1152/japplphysiol.00303.2019?rfr_dat=cr_pub++0pubmed&url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org-
dc.descriptionThis is the pre-peer reviewed version of the following article: Almendros, I., Martínez-Ros, P., Farré, N., Rubio-Zaragoza, M., Torres, M., Gutiérrez-Bautista, A.J. et al. (2019). Placental oxygen transfer reduces hypoxia-reoxygenation swings in fetal blood in a sheep model of gestational sleep apnea. Journal of Applied Physiology, vol. 127, i. 3 (13 sep.), pp. 745-752, which has been published in final form at https://doi.org/10.1152/japplphysiol.00303.2019.-
dc.descriptionEste es el pre-print del siguiente artículo: Almendros, I., Martínez-Ros, P., Farré, N., Rubio-Zaragoza, M., Torres, M., Gutiérrez-Bautista, A.J. et al. (2019). Placental oxygen transfer reduces hypoxia-reoxygenation swings in fetal blood in a sheep model of gestational sleep apnea. Journal of Applied Physiology, vol. 127, i. 3 (13 sep.), pp. 745-752, que se ha publicado de forma definitiva en https://doi.org/10.1152/japplphysiol.00303.2019.-
dc.description.abstractAIM: Obstructive sleep apnea (OSA), characterized by events of hypoxia reoxygenation, is highly prevalent in pregnancy, negatively affecting the gestation process and particularly the fetus. Whether the consequences of OSA on the fetus and offspring are mainly caused by systemic alterations in the mother or by direct effect of intermittent hypoxia in the fetus is unknown. In fact, how apnea-induced hypoxemic swings in OSA are transmitted across the placenta remains to be investigated. The aim of this study was to test the hypothesis, based on a theoretical background on the dampening effect of oxygen transfer in the placenta, that oxygen partial pressure (PO2) swings resulting from obstructive apneas mimicking OSA are mitigated in the fetal circulation. METHODS: To this end, 4 anesthetized ewes close to term pregnancy were subjected to obstructive apneas consisting of 25-s airway obstructions. Real time PO2 was measured in the maternal carotid artery and in the umbilical vein using fast-response fiberoptic oxygen sensors. RESULTS: The amplitude of PO2 swings in the umbilical vein were considerably smaller (3.1±1.0 vs. 21.0±6.1 mmHg (m±SE); p<0.05). Corresponding estimated swings in fetal and maternal oxyhemoglobin saturation tracked PO2 swings. CONCLUSION: This study provides novel insights into fetal oxygenation in a model of gestational OSA, and highlights the importance of further understanding the impact of sleep-disordered-breathing on fetal and offspring development.-
dc.formatapplication/pdf-
dc.language.isoes-
dc.language.isoen-
dc.publisherAmerican Physiological Society.-
dc.relationEsta trabajo de investigación fue financiado parcialmente por el Ministerio de Ciencia, Innovación y Universidades del Gobierno de España (SAF2017-85574-R).-
dc.relationUCH. Financiación Nacional-
dc.relation.ispartofJournal of Applied Physiology, vol. 127, i. 3 (1 sep. 2019).-
dc.rightshttp://creativecommons.org/licenses/by-nc-nd/4.0/deed.es-
dc.subjectFetal blood.-
dc.subjectSangre fetal.-
dc.subjectSueño - Trastornos.-
dc.subjectSleep disorders.-
dc.subjectFetal anoxia.-
dc.subjectEmbarazo - Complicaciones y secuelas.-
dc.subjectAnoxia fetal.-
dc.subjectOxygen in the body.-
dc.subjectPregnancy - Complications.-
dc.subjectOxígeno en el organismo.-
dc.titlePlacental oxygen transfer reduces hypoxia-reoxygenation swings in fetal blood in a sheep model of gestational sleep apnea-
dc.typeArtículo-
dc.description.versionPreprint-
dc.identifier.doihttps://doi.org/10.1152/japplphysiol.00303.2019-
dc.relation.projectIDSAF2017-85574-R-
dc.centroUniversidad Cardenal Herrera-CEU-
Aparece en las colecciones: Dpto. Producción y Sanidad Animal, Salud Pública Veterinaria y Ciencia y Tecnología de los Alimentos




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