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High-performace liquid chromatographic analysis of dextromethorphan guaifenesin and benzoate in a cough syrup for stability testing.


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Título : High-performace liquid chromatographic analysis of dextromethorphan guaifenesin and benzoate in a cough syrup for stability testing.
Autor : Galli, Verónica
Barbas Arribas, Coral.
Materias: AnalysisCough syrupValidationForced degradation
Resumen : A method has been developed for the analysis of a cough syrup containing dextromethorphan, guaifenesin, benzoic acid, saccharin and other components. Forced degradation was also studied to demonstrate that the method could be employed during a stability study of the syrup. Final conditions were phosphate buffer (25 mM, pH 2.8) with triethylamine (TEA)–acetonitrile (75:25, v/v). In such conditions, all the actives, excipients and degradation products were baseline resolved in less than 14 min, and different wavelengths were used for the different analytes and related compounds.
Descripción : En: Journal of chromatography A. ISSN 0021-9673, 2004. n. 1048 : 207-211 p.
URI : http://hdl.handle.net/10637/1084
Derechos: http://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
Fecha de publicación : 19-sep-2004
Centro : Universidad San Pablo-CEU
Aparece en las colecciones: Facultad de Farmacia





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