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dc.contributor.otherUCH. Departamento de Odontología-
dc.contributor.otherProducción Científica UCH 2018-
dc.creatorJun, Soo-Kyunges
dc.creatorYang, Sun-A.es
dc.creatorKim, You-Jines
dc.creatorEl-Fiqi, Ahmedes
dc.creatorMandakhbayar, Nandines
dc.creatorKim, Duck-Sues
dc.creatorSauro, Salvatore.es
dc.date2018es
dc.date.accessioned2019-07-08T11:44:33Z-
dc.date.available2019-07-08T11:44:33Z-
dc.date.issued2018-04-04-
dc.identifier.citationJun, SK., Yang, SA., Kim, YJ, El-Fiqui, A., Mandakhbayar, N., Kim, DS. et al. (2018). Multi-functional nano-adhesive releasing therapeutic ions for MMP-deactivation and remineralization. Scientific Reports, vol. 8 (april), art. 5663. DOI: https://doi.org/10.1038/s41598-018-23939-6-
dc.identifier.issn2045-2322.-
dc.identifier.urihttp://hdl.handle.net/10637/10505-
dc.descriptionEste artículo se encuentra disponible en la página web de la revista en la siguiente URL: https://www.nature.com/articles/s41598-018-23939-6es
dc.description.abstractRestoration of hard tissue in conjunction with adhesive is a globally challenging issue in medicine and dentistry. Common clinical therapies involving application of adhesive and substitute material for functional or anatomical recovery are still suboptimal. Biomaterials with bioactivity and inhibitory effects of enzyme-mediated adhesive degradation can render a solution to this. Here, we designed a novel copper-doped bioactive glass nanoparticles (CuBGn) to offer multifunction: metalloproteinases (MMP) deactivation and remineralization and incorporated the CuBGn in resin-dentin adhesive systems, which showed most common failure of MMP mediated adhesive degradation among hard tissue adhesives, to evaluate proposed therapeutic effects. A sol-gel derived bioactive glass nanoparticles doping 10 wt% of Cu (Cu-BGn) for releasing Cu ions, which were well-known MMP deactivator, were successfully created and included in light-curing dental adhesive (DA), a filler-free co-monomer resin blend, at different concentrations (up to 2 wt%). These therapeutic adhesives (CuBGn-DA) showed enhanced (a)cellular bioactivity, cytocompatibility, microtensile bond strength and MMP deactivationability. In conclusion, the incorporation of Cu ions releasing nano-bioactive glass demonstrated multifunctional properties at the resin-dentin interface; MMP deactivation and remineralization, representing a suitable strategy to extend the longevity of adhesive-hard tissue (i.e. resin-dentin) interfaces.-
dc.formatapplication/pdfes
dc.language.isoenes
dc.publisherSpringer Nature Publishing AG-
dc.relationEste artículo fue subvencionado por la National Research Foundation of Korea (NRF) del Gobierno de Korea (MSIT) (NRF-2015R1C1A1A01052127, NRF-2015R1A2A2A0100756745, y NRF-2018R1A2B3003446). También fue apoyado por una beca de investigación de la Universidad CEU Cardenal Herrera (INDI16/34 y INDI1527B) del Programa de Consolidación de Indicadores: Fomento Plan Estatal CEU-UCH 2014-2017.-
dc.relationUCH. Financiación Universidad.-
dc.relation.ispartofScientific Reports, vol. 8 (april 2018).-
dc.rightshttp://creativecommons.org/licenses/by/4.0/deed.eses
dc.subjectDental materials.es
dc.subjectMateriales biomédicos.es
dc.subjectAdhesivos dentales.es
dc.subjectBiomedical materials.es
dc.subjectGums and resins in Dentistry.es
dc.subjectCementos dentales.es
dc.subjectDental cements.es
dc.subjectMateriales dentales.es
dc.subjectGomas y resinas - Aplicaciones en Odontología.es
dc.subjectDental adhesives.es
dc.titleMulti-functional nano-adhesive releasing therapeutic ions for MMP-deactivation and remineralizationes
dc.typeArtículoes
europeana.dataProviderUNIVERSIDAD SAN PABLO CEU-
europeana.isShownAthttp://hdl.handle.net/10637/10252-
europeana.objecthttp://repositorioinstitucional.ceu.es/visor/libros/709934/thumb_europeana/709934.jpg-
europeana.providerHispana-
europeana.rightshttp://creativecommons.org/publicdomain/zero/1.0/-
europeana.typeTEXT-
dc.identifier.doihttps://doi.org/10.1038/s41598-018-23939-6-
dc.relation.projectIDNRF-2015R1C1A1A01052127-
dc.relation.projectIDNRF-2015R1A2A2A0100756745-
dc.relation.projectIDNRF-2018R1A2B3003446-
dc.relation.projectIDINDI16/34-
dc.relation.projectIDINDI1527B-
dc.centroUniversidad Cardenal Herrera-CEU-
Aparece en las colecciones: Dpto. Odontología




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