Urinary excretion of nitrogenous compounds and ketones in streptozotocin treated rats.

Abstract

During the second and third day after the intraperitoneal injection of 65 mg/kg of streptozotocin to rats the daily urinary excretion of urea, ammonia and ketone bodies is significantly elevated over levels seen in control rats. The streptozotocin treated rats show polyuria but the excretion of urinary creatinine did not differ from that in the controls. Fasted animals showed no significant differences between streptozotocin treated animals and control groups in all parameters measured. The results have been related with the in vi'fo utilization of aminoacids in diabetes to maintain elevated liver and renal gluconeogenesis.