Buscar por Materia I. The effects of alcohol on brain monoamines were studied in 15-day-old offspring of rats given ethanol until th.: 21st day of gestation or the 15th day postpartum. 2. Increased noradrenaline concentrations were found in limbic system, hemispheres, diencephalon and brain ste:n of pups from mcthers under alcohol treatment. and in hemispheres, diencephalon and brain stem of pups from deprived mothers. 3. Serotonin and 5-hydroxyindol acetic acid were augmented in limbic system, diencephalon and brain stem of pups from mothers under alcohol whereas tyrosine was decreased in all brain regions studied in pups from alcoholic and deprived mothers. 4. Consequently, chronic ethanol ingestion by pregnar,t rats has deleterious effects on CNS devdopment of 15-day-old offspring which persists 15 days after alcohol withdrawal.

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