Please use this identifier to cite or link to this item: http://hdl.handle.net/10637/15424
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dc.contributor.otherUniversidad San Pablo-CEU. Facultad de Medicina.-
dc.contributor.otherGrupo: Centro de metabolómica y bioanálisis (CEMBIO)-
dc.creatorSoler Palacios, Blanca-
dc.creatorVillares, Ricardo-
dc.creatorLucas, Pilar-
dc.creatorRodríguez-Frade, José Miguel-
dc.creatorCayuela, Ana-
dc.creatorPiccirillo, Jonathan G.-
dc.creatorLombardía, Manuel-
dc.creatorDelgado Gestoso, David-
dc.creatorFernández García, Miguel-
dc.creatorRisco, Cristina-
dc.creatorBarbas Arribas, Coral.-
dc.creatorCorrales, Fernando-
dc.creatorSorzano Sánchez, Carlos Óscar-
dc.creatorMartínez-Martín, Nuria-
dc.creatorConesa, José Javier-
dc.creatorIborra, Francisco J.-
dc.creatorMellado, Mario-
dc.date.accessioned2024-02-09T14:51:17Z-
dc.date.available2024-02-09T14:51:17Z-
dc.date.issued2023-07-05-
dc.identifier.citationSoler Palacios B, Villares R, Lucas P, Rodríguez-Frade JM, Cayuela A, Piccirillo JG, Lombardía M, Delgado Gestoso D, Fernández-García M, Risco C, Barbas C, Corrales F, Sorzano COS, Martínez-Martín N, Conesa JJ, Iborra FJ, Mellado M. Growth hormone remodels the 3D-structure of the mitochondria of inflammatory macrophages and promotes metabolic reprogramming. Front Immunol. 2023 Jul 5;14:1200259. doi: 10.3389/fimmu.2023.1200259. PMID: 37475858; PMCID: PMC10354525.es_ES
dc.identifier.issn1664-3224-
dc.identifier.urihttp://hdl.handle.net/10637/15424-
dc.description.abstractIntroduction: Macrophages are a heterogeneous population of innate immune cells that support tissue homeostasis through their involvement in tissue development and repair, and pathogen defense. Emerging data reveal that metabolism may control macrophage polarization and function and, conversely, phenotypic polarization may drive metabolic reprogramming. Methods: Here we use biochemical analysis, correlative cryogenic fluorescence microscopy and cryo-focused ion-beam scanning electron microscopy. Results: We demonstrate that growth hormone (GH) reprograms inflammatory GM-CSF-primed monocyte-derived macrophages (GM-MØ) by functioning as a metabolic modulator. We found that exogenous treatment of GM-MØ with recombinant human GH reduced glycolysis and lactate production to levels similar to those found in anti-inflammatory M-MØ. Moreover, GH treatment of GM-MØ augmented mitochondrial volume and altered mitochondrial dynamics, including the remodeling of the inner membrane to increase the density of cristae. Conclusions: Our data demonstrate that GH likely serves a modulatory role in the metabolism of inflammatory macrophages and suggest that metabolic reprogramming of macrophages should be considered as a new target to intervene in inflammatory diseases.en_EN
dc.formatapplication/pdf-
dc.language.isoen-
dc.publisherFrontiers Media-
dc.relation.ispartofFrontiers in Immunology-
dc.rightshttp://creativecommons.org/licenses/by-nc-nd/4.0/deed.es-
dc.subjectCryo-FIB/SEMen_EN
dc.subjectGrowth hormoneen_EN
dc.subjectMacrophagesen_EN
dc.subjectMetabolismen_EN
dc.subjectMitochondriaen_EN
dc.titleGrowth hormone remodels the 3D-structure of the mitochondria of inflammatory macrophages and promotes metabolic reprogrammingen_EN
dc.typeArtículoes_ES
dc.identifier.doi10.3389/fimmu.2023.1200259-
dc.centroUniversidad San Pablo-CEU-
Appears in Collections:Medicina




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