The management of the ovine estrous cycle is mainly based on the use of exogenous hormones for mimicking (progesterone and its analogues) or manipulating (prostaglandin F2α and its analogues) the activity of the corpus luteum, combined with the application of other hormones mimicking the pituitary secretion of gonadotrophins (e.g.: equine chorionic gonadotrophin, eCG). These protocols have been applied without major change for decades but, now, there are two reasons to reconsider them: i) our greatly improved knowledge of the dynamics of ovarian physiology, following the application of transrectal ultrasonography, indicates that modification of the protocols may improve the yields; ii) increasing concerns about animal health and welfare, food safety and the environmental impact of the treatments, as evidenced by public opinion and therefore market forces. Here, we offer an overview of these issues, introduce an updated protocol, and suggest ways for future improvements of the protocols.