Phytochemical Analysis and Anti-Inflammatory Potential of Acanthus mollis L. Rhizome Hexane Extract

dc.centroUniversidad San Pablo-CEU
dc.contributor.authorAcero de Mesa, Nuria
dc.contributor.authorMuñoz Mingarro, Dolores
dc.contributor.authorNavarro, Inmaculada
dc.contributor.authorLeón-González, Antonio J.
dc.contributor.authorMartín-Cordero, Carmen
dc.contributor.otherUniversidad San Pablo-CEU. Facultad de Farmacia
dc.contributor.otherGrupo: Productos naturales (CEU-PRONAT)
dc.date.accessioned2024-04-09T12:34:20Z
dc.date.available2024-04-09T12:34:20Z
dc.date.issued2023-01-22
dc.description.abstractThe rhizomes of Acanthus mollis have traditionally been used for the treatment of several ailments involving inflammation. However, to the best of our knowledge, their chemical composition and pharmacological properties have not been studied until now. As a first approach, this study analyses the A. mollis rhizome hexane extract phytochemistry and its anti-inflammatory and antioxidant capacities in HepG2 and RAW 264.7 cell culture assays. Chemical profiling was performed with gas chromatography mass spectrometry without the modification of native molecules. Free phytosterols (such as -sitosterol) account for 70% of detected compounds. The anti-inflammatory capacity of the rhizome extract of A. mollis is mediated by the decrease in the NO production in RAW 264.7 that has previously been stimulated with lipopolysaccharide in a dose-dependent manner. Furthermore, HepG2 pre-treatment with the rhizome extract prevents any damage being caused by oxidative stress, both through ROS scavenge and through the antioxidant cellular enzyme system. In this respect, the extract reduced the activity of glutathione peroxidase and reductase, which were stimulated under oxidative stress conditions. Our results suggest that the extract from the rhizomes of A. mollis may constitute a potential source of natural products with anti-inflammatory activity and could validate the traditional use of A. mollis.en_EN
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dc.identifier.citationAcero, N.; Muñoz-Mingarro, D.; Navarro, I.; León-González, A.J.; Martín-Cordero, C. Phytochemical Analysis and Anti-Inflammatory Potential of Acanthus mollis L. Rhizome Hexane Extract. Pharmaceuticals 2023, 16, 159. https://doi.org/10.3390/ph16020159es_ES
dc.identifier.doi10.3390/ph16020159
dc.identifier.issn1424-8247
dc.identifier.urihttp://hdl.handle.net/10637/15709
dc.language.isoen
dc.publisherMDPI
dc.relation.ispartofPharmaceuticals
dc.relation.projectIDFunded by the Fundación Universitaria San Pablo-CEU and Banco de Santander (PPC 20/2015).
dc.rightsopen access
dc.rights.cchttps://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subjectAcanthus mollisen_EN
dc.subjectAcanthaceaeen_EN
dc.subjectAnti-inflammatory activityen_EN
dc.subjectPhytosterolsen_EN
dc.titlePhytochemical Analysis and Anti-Inflammatory Potential of Acanthus mollis L. Rhizome Hexane Extracten_EN
dc.typeArtículoes_ES
dspace.entity.typePublicationes
relation.isAuthorOfPublicationf213828d-43c9-4786-ae19-02a192f886fe
relation.isAuthorOfPublication.latestForDiscoveryf213828d-43c9-4786-ae19-02a192f886fe

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