Extracellular vesicles from mesenchymal stem cells as novel treatments for musculoskeletal diseases

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dc.centroUniversidad Cardenal Herrera-CEU
dc.contributor.authorAlcaraz Tormo, María José
dc.contributor.authorCompañ, Álvaro
dc.contributor.authorGuillén Salazar, Isabel
dc.contributor.otherProducción Científica UCH 2020
dc.contributor.otherUCH. Departamento de Farmacia
dc.date2020
dc.date.accessioned2021-05-12T04:00:09Z
dc.date.available2021-05-12T04:00:09Z
dc.date.issued2019-12-31
dc.descriptionEste artículo se encuentra disponible en la siguiente URL: https://www.mdpi.com/2073-4409/9/1/98
dc.descriptionEste artículo pertenece al número especial "Therapeutic applications of extracellular vesicles".
dc.description.abstractMesenchymal stem/stromal cells (MSCs) represent a promising therapy for musculoskeletal diseases. There is compelling evidence indicating that MSC e ects are mainly mediated by paracrine mechanisms and in particular by the secretion of extracellular vesicles (EVs). Many studies have thus suggested that EVs may be an alternative to cell therapy with MSCs in tissue repair. In this review, we summarize the current understanding of MSC EVs actions in preclinical studies of (1) immune regulation and rheumatoid arthritis, (2) bone repair and bone diseases, (3) cartilage repair and osteoarthritis, (4) intervertebral disk degeneration and (5) skeletal muscle and tendon repair. We also discuss the mechanisms underlying these actions and the perspectives of MSC EVs-based strategies for future treatments of musculoskeletal disorders.
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dc.identifier.citationAlcaraz, M.J., Compañ, A. & Guillén, M.I. (2019). Extracellular vesicles from mesenchymal stem cells as novel treatments for musculoskeletal diseases. Cells, vol. 9, i. 1 (31 dec.), art. 98. DOI: https://doi.org/10.3390/cells9010098
dc.identifier.doihttps://doi.org/10.3390/cells9010098
dc.identifier.issn2073-4409 (Electrónico)
dc.identifier.urihttp://hdl.handle.net/10637/12582
dc.language.isoes
dc.language.isoen
dc.publisherMDPI
dc.relationEste trabajo de investigación ha sido financiado a través de una beca del Ministerio de Ciencia, Innovación y Universidades del Gobierno de España y de Fondos FEDER (SAF2017-85806-R).
dc.relationUCH. Financiación Europea
dc.relationUCH. Financiación Nacional
dc.relation.ispartofCells, vol. 9, n. 1.
dc.relation.projectIDSAF2017-85806-R
dc.rightsopen access
dc.rights.cchttps://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subjectOsteoartritis - Tratamiento.
dc.subjectOsteoarthritis - Treatment.
dc.subjectStem cells - Therapeutic use.
dc.subjectSistema musculoesquelético - Enfermedades - Tratamiento.
dc.subjectMusculoskeletal system - Diseases - Treatment.
dc.subjectCélulas madre - Uso terapéutico.
dc.titleExtracellular vesicles from mesenchymal stem cells as novel treatments for musculoskeletal diseases
dc.typeArtículo
dspace.entity.typePublicationes
relation.isAuthorOfPublicationc4376958-fc57-4066-a49d-6bbcadd31085
relation.isAuthorOfPublication.latestForDiscoveryc4376958-fc57-4066-a49d-6bbcadd31085

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