The autologous chondral platelet-rich plasma matrix implantation: a new therapy in cartilage repair and regeneration: macroscopic and biomechanical study in an experimental sheep model

dc.centroUniversidad Cardenal Herrera-CEU
dc.contributor.authorSopena Juncosa, Joaquín Jesús
dc.contributor.authorTorres Torrillas, Marta
dc.contributor.authorCarrillo Poveda, José María
dc.contributor.authorCuervo Serrato, Belén
dc.contributor.authorDamiá Giménez, Elena
dc.contributor.authorSantana, Angelo
dc.contributor.authorCugat Bertomeu, Ramón
dc.contributor.authorVilar, José M.
dc.contributor.authorHernández Guerra, Ángel María
dc.contributor.authorRomero Martínez, Ayla del
dc.contributor.authorMiguel Pastor, Laura
dc.contributor.authorPeláez Gorrea, Pau
dc.contributor.authorRubio Zaragoza, Mónica
dc.contributor.otherUCH. Departamento de Medicina y Cirugía Animal
dc.contributor.otherUCH. Cátedra de Fundación García Cugat
dc.contributor.otherUCH. Grupo de Investigación en Medicina Biorregenerativa y Cirugía Aplicada (BIOMED-SURGERY)
dc.date.accessioned2024-02-01T10:06:23Z
dc.date.available2024-02-01T10:06:23Z
dc.date.issued2023-12-11
dc.description.abstractIntroduction: Articular cartilage injuries are a severe problem, and the treatments for these injuries are complex. The present study investigates a treatment for full-thickness cartilage defects called Autologous Chondral Platelet Rich Plasma Matrix Implantation (PACI) in a sheep model. Methods: Chondral defects 8 mm in diameter were surgically induced in the medial femoral condyles of both stifles in eight healthy sheep. Right stifles were treated with PACI and an intraarticular injection with a plasma rich in growth factors (PRGF) solution [treatment group (TRT)], while an intraarticular injection of Ringer’s lactate solution was administered in left stifles [Control group (CT)]. The limbs’ function was objectively assessed with a force platform to obtain the symmetry index, comparing both groups. After 9 and 18 months, the lesions were macroscopically evaluated using the International Cartilage Repair Society and Goebel scales. Results: Regarding the symmetry index, the TRT group obtained results similar to those of healthy limbs at 9 and 18 months after treatment. Regarding the macroscopic assessment, the values obtained by the TRT group were very close to those of normal cartilage and superior to those obtained by the CT group at 9 months. Conclusion: This new bioregenerative treatment modality can regenerate hyaline articular cartilage. High functional outcomes have been reported, together with a good quality repair tissue in sheep. Therefore, PACI treatment might be a good therapeutic option for full-thickness chondral lesions.es_ES
dc.identifier.citationPeláez-Gorrea, P., Damiá-Giménez, E., Rubio-Zaragoza, M., Cuervo-Serrato, B., Hernández-Guerra, Á.M., Miguel-Pastor, L., Del Romero-Martínez, A., Sopena-Juncosa, J., Torres-Torrillas, M., Santana, A., Cugat-Bertomeu, R., Vilar-Guereño, J.M. & Carrillo-Poveda, J.M. (2023). The autologous chondral platelet-rich plasma matrix implantation: a new therapy in cartilage repair and regeneration: macroscopic and biomechanical study in an experimental sheep model. Frontiers in Veterinary Science, vol. 10, art. 1223825 (11 dec.). DOI: https://doi.org/10.3389/fvets.2023.1223825es_ES
dc.identifier.doihttps://doi.org/10.3389/fvets.2023.1223825
dc.identifier.issn2297-1769 (Electrónico)
dc.identifier.urihttp://hdl.handle.net/10637/15265
dc.language.isoenes_ES
dc.publisherFrontiers Mediaes_ES
dc.relationUCH. Financiación Universidad
dc.relationEste artículo de investigación ha sido financiado por la Cátedra de Fundación García Cugat y por la Fundación Santander (FUSPBS-PPC03/2017).
dc.relation.ispartofFrontiers in Veterinary Science, vol. 10
dc.relation.projectIDFUSPBS-PPC03/2017
dc.rightsopen access
dc.rights.cchttps://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subjectCartílagoses_ES
dc.subjectCartilagees_ES
dc.subjectPlasma sanguíneoes_ES
dc.subjectBlood plasmaes_ES
dc.subjectFactores de crecimientoes_ES
dc.subjectGrowth factorses_ES
dc.subjectTerapiaes_ES
dc.subjectTherapyes_ES
dc.subjectRegeneraciónes_ES
dc.subjectRegenerationes_ES
dc.titleThe autologous chondral platelet-rich plasma matrix implantation: a new therapy in cartilage repair and regeneration: macroscopic and biomechanical study in an experimental sheep modeles_ES
dc.typeArtículoes_ES
dspace.entity.typePublicationes
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