Background/Objective:Theaimofthestudywastoexaminethefactorstructureandpsy-chometricpropertiesoftheSpanishversionoftheMini-MentalAdjustmenttoCancerScale(Mini-MAC)inalargesampleofpatientswithnon-metastatic,resectedcancer.Methods:Prospective,observational,multicenterstudyforwhich914patientswererecruitedfrom15Spanishhospitals.Exploratoryandconfirmatoryfactoranalyses,validityandreliabilityanalyseswereconducted.Results:Factor-analyticresultsindicateda4-factorstructureoftheSpanishversionoftheMini-MAC.ThreesubscaleshavepsychometricpropertiessimilartothoseofHelplessness,Anxiouspreoccupation,andCognitiveavoidanceoftheoriginaltheMini-MAC.TheFightingspiritandtheFatalismsubscaleswerecombinedonthePositiveattitudescale.Thefourfactor-derivedscalescoresexhibitedacceptableaccuracyforindividualmeasurementpurposes,aswellasstabilityovertimeintest-retestassessmentsat6months.Validityassessmentsfoundmeaningfulrelationsbetweenthederivedscalescores,andBriefSymptomInventorydepressionandanxietyscoresandFunctionalAssessmentofChronicIllnessTherapyspiritualwell-beingscores.Conclusions:TheSpanishversionoftheMini-MACprovidesreliableandvalidmeasuresforpatientswithnon-metastatic,resectedcancer,andresultscorroboratetheinstrument’scross-culturalvalidity