Omics technologies are based on the acquisition and analysis of a large data volumes, using fast and automated high-performance methods. They have brought along a paradigm shift in the development of research strategies. Genomics, Epigenomics, Transcriptomics, Proteomics and Metabolomics are by now widely applied to identify biological variants, to characterize complex biochemical systems, to study pathophysiological processes and to define new biomarker strategies (Figure 1). Each omics discipline provides different information on the regulation of gene expression in health and diseases such as asthma.